abstract：:A classical drug repurposing approach was applied to find new putative GPR40 allosteric binders. A two-step computational protocol was set up, based on an initial pharmacophoric-based virtual screening of the DrugBank database of known drugs, followed by docking simulations to confirm the interactions between the prio...

authors： Cione E,Caroleo MC,Kagechika H,Manetti F

更新日期：2021-12-01 00:00:00

abstract：:The article describes the oldest locations and buildings for the treatment of patients in Rijeka. According to historical sources, the first known site for health care and treatment was a hospital founded in the 14th or 15th century in the Old Town, in the St Sebastian Street, in which also existed a little church of ...

authors： Palinić N

更新日期：2021-12-01 00:00:00

abstract：:Preeclampsia (PE) is an important topic in obstetrics. In this study, we used weighted gene co-expression network analysis (WGCNA) to screen the key modules related to immune cell infiltration and to identify the hub genes for the molecular subtyping of PE. We first downloaded a set of PE transcriptional data (GSE7501...

authors： Meng Y,Li C,Liu CX

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVE:HOTAIR has been well reported to be involved in the drug resistance of many diseases. This study aims to explore the possible implication of HOTAIR in doxorubicin (ADM) resistance in acute myeloid leukemia (AML). METHODS:Expressions of HOTAIR and PTEN in bone marrows of patient with newly diagnosed AML and r...

authors： Zhou W,Xu S,Chen X,Wang C

更新日期：2021-12-01 00:00:00

abstract：:The prognostic significance of miR-24 in tumors has not been determined. Therefore, we conducted a meta-analysis to systematically assess the correlation between miR-24 and its prognostic value in cancers PubMed, EMBASE, and Web of Science databases were used to search relevant articles (up to 1 October 2020). Studies...

authors： Liu R,Kong W,Zheng S,Yu C,Yu Y,Xu Y,Ye L,Shao Y

更新日期：2021-12-01 00:00:00

abstract：:Adhesins facilitate bacterial colonization and invasion of host tissues and are considered virulence factors, but their impact on immune-mediated damage as a driver of pathogenesis remains unclear. Yersinia pseudotuberculosis encodes for a multivalent adhesion molecule (MAM), a mammalian cell entry (MCE) family protei...

authors： Krachler AM,Sirisaengtaksin N,Monteith P,Paine CET,Coates CJ,Lim J

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Alantolactone, the bioactive component in Inula helenium L. (Asteraceae), exhibits multiple biological effects. OBJECTIVE:We aimed to determine the anti-inflammatory effect of alantolactone in a collagen-induced arthritis (CIA) mouse model and its immunomodulatory effects on Th17 differentiation. MATERIALS AN...

authors： Chen HL,Lin SC,Li S,Tang KT,Lin CC

更新日期：2021-12-01 00:00:00

abstract：:In development of peptide therapeutics, rodents are commonly-used preclinical models when screening compounds for efficacy endpoints in the early stages of discovery projects. During the screening process, some peptides administered subcutaneously to rodents caused injection site reactions manifesting as localized swe...

authors： John LM,Dalsgaard CM,Jeppesen CB,Conde-Frieboes KW,Baumann K,Knudsen NPH,Skov PS,Wulff BS

更新日期：2021-12-01 00:00:00

abstract：:Formation of higher-order supramolecular complexes has emerged as a common principle underlying activity of a number of immune and regulated cell-death signalling pathways in animals, plants and fungi. Some of these signalosomes employ functional amyloid motifs in their assembly process. The description of such system...

authors： Daskalov A,Saupe SJ

更新日期：2021-12-01 00:00:00

abstract：:Globally, women, experience inequities in access to safe abortion services and this is most acutely felt in country contexts where legal abortions are highly restricted. Data around abortion amongst young women who sell sex (YWSS) in sub-Saharan Africa are very limited. We conducted 30 focus group discussions and 42 i...

authors： Chareka S,Crankshaw TL,Zambezi P

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the role of prophylactic use of statin in venous thromboembolism (VTE) in patients with primary membranous nephropathy (PMN). METHODS:A total of 734 patients with PMN were consecutively enrolled in this retrospective study. 564 patients had received statins prescripti...

authors： Zou P,Li H,Cai J,Chen Z,Li C,Li X

更新日期：2021-12-01 00:00:00

abstract：:The development of suitable drug delivery carriers is significant in biomedical applications to improve the therapeutic efficiency. Recent progress in nanotechnological fields, paved the way for the formulation of variety of drug carriers. The brain disorders such as ischemic stroke, brain cancer, and CNS disorders we...

authors： Lu X,Zhang Y,Wang L,Li G,Gao J,Wang Y

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVE:As COVID-19 is a new emerging disease, the hematological/immunological changes that develop in the infected patients remain unknown. This study aims to systematically review the hematologic autoimmune complications in these patients. METHOD:Data from three online databases including Medline (via PubMed), Sco...

authors： Taherifard E,Taherifard E,Movahed H,Mousavi MR

更新日期：2021-12-01 00:00:00

abstract：:Long non-coding RNA breast cancer antiestrogen resistance 4 (lncRNA BCAR4) is an independent factor on the survival prognosis of patients with multiple cancers. However, the role of lncRNA BCAR4 in esophageal squamous cell cancer (ESCC) remains unknown. Here, we unraveled that lncRNA BCAR4 was upregulated in ESCC and ...

authors： Yan S,Xu J,Liu B,Ma L,Feng H,Tan H,Fang C

更新日期：2021-12-01 00:00:00

abstract：:A small library of coumarin and their psoralen analogues EMAC10157a-b-d-g and EMAC10160a-b-d-g has been designed and synthesised to investigate the effect of structural modifications on their inhibition ability and selectivity profile towards carbonic anhydrase isoforms I, II, IX, and XII. None of the new compounds ex...

authors： Meleddu R,Deplano S,Maccioni E,Ortuso F,Cottiglia F,Secci D,Onali A,Sanna E,Angeli A,Angius R,Alcaro S,Supuran CT,Distinto S

更新日期：2021-12-01 00:00:00

abstract：:Hyaluronan (HA) is abundant in the skin; while HA can be synthesized by the synthases (HAS1-3), HAS2 is the leading contributor. Dysregulation and accumulation of HA is implicated in the pathogenesis of diseases such as keloid scarring, lymphedema and metastatic melanoma. To understand how HA synthesis contributes to ...

authors： Steen EH,Short WD,Li H,Parikh UM,Blum A,Templeman N,Nagy N,Bollyky PL,Keswani SG,Balaji S

更新日期：2021-12-01 00:00:00

abstract：:Multiple mini-interview (MMI) is a 'multiple sample-based' approach comprising multiple focused encounters intended to access and assess a range of attributes in order to gain more objectively multiple impressions of an applicant's interpersonal skills, thoughtfulness and general demeanour. It is designed to focus on ...

authors： Kok KY,Chen L,Idris FI,Mumin NH,Ghani H,Zulkipli IN,Lim MA

更新日期：2021-12-01 00:00:00

abstract：:Human adenovirus (HAdV) species B can cause severe acute respiratory diseases. However, the researches to combat this infection have been hampered by the lack of an animal model permissive to the virus. Here, we report in vitro and in vivo HAdV species B infections of tree shrews, the closest relative of primates. HAd...

authors： Li X,Zhou Z,Liu W,Fan Y,Luo Y,Li K,Zheng Z,Tian X,Zhou R

更新日期：2021-12-01 00:00:00

abstract：:We conducted a scoping review to map the extent, range and nature of the scientific research literature on the reproductive health (RH) of transgender and gender diverse assigned female at birth and assigned male at birth persons. A research librarian conducted literature searches in Ovid MEDLINE®, Ovid Embase, the Co...

authors： Agénor M,Murchison GR,Najarro J,Grimshaw A,Cottrill AA,Janiak E,Gordon AR,Charlton BM

更新日期：2021-12-01 00:00:00

abstract：PURPOSE:QX003S is a biosimilar candidate for the reference tocilizumab, Actemra®. We investigated the tolerance, variability, and pharmacokinetics (PK) of QX003S biosimilar in healthy Chinese male subjects. DESIGN:A randomised, double-blind, two-arm, parallel study was performed to examine the bioequivalence of QX003S...

authors： Zhang H,Li X,Liu J,Li C,Wu M,Zhu X,Sun J,Fang M,Ding Y

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:Health-related quality of life (HRQL) is a key factor in making anticoagulant treatment decisions. The objective of this study was to assess the HRQL of patients with nonvalvular atrial fibrillation by treatment type: direct oral anticoagulants (DOACs) or vitamin K antagonists (VKAs). METHODS:We carried out...

authors： Gabilondo M,Loza J,Pereda A,Caballero O,Zamora N,Gorostiza A,Mar J

更新日期：2021-12-01 00:00:00

abstract：INTRODUCTION:Calciphylaxis is a rare but potentially fatal disease commonly occurred in dialysis patients. Despite some previous studies on risk factors for calciphylaxis, there is still a lack of data from Chinese population. METHODS:The retrospective matched case-control study about calciphylaxis was performed in Zh...

authors： Liu Y,Zhang X,Xie X,Yang X,Liu H,Tang R,Liu B

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Uremia induces various pathologic changes in the endothelium. However, there is limited information about the differences of these effects in endothelial cells originating from different parts of the vascular tree. METHODS:The effect of uremic serum obtained from patients with end stage renal failure on the...

authors： Sosińska-Zawierucha P,Bręborowicz A

更新日期：2021-12-01 00:00:00

abstract：:'Mother-to-child transmission of HIV' can occur during the period of pregnancy, childbirth, or breastfeeding. 'Prevention of mother-to-child transmission of HIV' (PMTCT) in Mpumalanga Province, South Africa, is especially vital as the prevalence of HIV is 28.2% in women aged 15-49. PMTCT interventions resulted in a dr...

authors： Jones DL,Rodriguez VJ,Soni Parrish M,Kyoung Lee T,Weiss SM,Ramlagan S,Peltzer K

更新日期：2021-12-01 00:00:00

abstract：:Vascular aging has been closely associated with various cardiovascular disorders; however, its molecular mechanism remains poorly understood. In our study, RNA sequencing was utilized to explore the expression profiles of long non-coding RNAs (lncRNAs) and mRNAs in the thoracic aortas of young (3 weeks) and old (16 we...

authors： Li Q,Xiao Z,Wang Y,Liu X,Liu H,Luo Z,Zheng S

更新日期：2021-12-01 00:00:00

abstract：:Pandemic influenza, typically caused by the reassortment of human and avian influenza viruses, can result in severe or fatal infections in humans. Timely identification of potential pandemic viruses must be a priority in influenza virus surveillance. However, the range of host species responsible for the generation of...

authors： Sun H,Li F,Liu Q,Du J,Liu L,Sun H,Li C,Liu J,Zhang X,Yang J,Duan Y,Bi Y,Pu J,Sun Y,Tong Q,Wang Y,Du X,Shu Y,Chang KC,Liu J

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Acquired von Willebrand syndrome (AVWS) is a rare, frequently underdiagnosed and underestimated bleeding disorder. Careful personal and family history and late-onset mucocutaneous bleeding could help clarify the etiology of bleeding deficiency. CASE PRESENTATION:An 82-year-old male patient was admitted to o...

authors： Magyari F,Kracskó B,Bedekovics J,Bereczky Z,Illés Á,Schlammadinger Á

更新日期：2021-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) are vital gene regulators, which play a profound role in the process of forming and developing many diseases, especially tumour. The study intends to excavate the potential regulatory mechanisms of miR-557 and its targeting gene Homeobox B9 (HOXB9) in osteosarcoma. GEO dataset on osteosarcoma was ap...

authors： Wang Y,Hao W,Wang H

更新日期：2021-12-01 00:00:00

abstract：:Enterovirus A71 (EV-A71) inactivated vaccines have been widely inoculated among children in Kunming City after it was approved. However, there was a large-scale outbreak of Enteroviruses (EVs) infection in Kunming, 2018. The epidemiological characteristics of HFMD and EVs were analysed during 2008-2018, which are befo...

authors： Jiang H,Zhang Z,Rao Q,Wang X,Wang M,Du T,Tang J,Long S,Zhang J,Luo J,Pan Y,Chen J,Ma J,Liu X,Fan M,Zhang T,Sun Q

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:A comprehensive understanding of vascular calcification pathology is significant for the development of cardiovascular disease therapy in high-risk populations. This cross-sectional study aimed to evaluate the prevalence and characteristics of radial artery calcification (RAC) and to identify the factors tha...

authors： Chen Z,Zhou Y,Yang T

更新日期：2021-12-01 00:00:00

abstract：:Circular RNAs (CircRNAs), belonging to non-coding RNAs, exert a crucial modulatory role in cancer progression. In this study, circRNA microarray analysis was utilized to screen differentially expressed circRNA in colorectal cancer (CRC) and circ_0000467 was identified as one circRNA whose expression was significantly ...

authors： Xie L,Pan Z

更新日期：2021-12-01 00:00:00

abstract：:Background: During the current COVID-19 pandemic, offline clinical education was mandated to suspend at the neurology department of many teaching hospitals globally, yet there is insufficient evidence regarding the preferred practice and methods for online neurology intern training course.Objective: The investigation ...

authors： He M,Tang XQ,Zhang HN,Luo YY,Tang ZC,Gao SG

更新日期：2021-12-01 00:00:00

abstract：:This study reports results of a life course study conducted with Inuit in Nunavik to obtain information on the life adversities and cumulative burden of adversity for three groups: those who died by suicide, those who attempted suicide, and those who experienced suicidal ideation but never attempted. The study involve...

authors： Affleck W,Chawky N,Beauchamp G,Inukpuk MM,Annanack E,Paradis V,Séguin M

更新日期：2021-12-01 00:00:00

abstract：:The unprecedented coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a serious threat to global public health. Development of effective therapies against SARS-CoV-2 is urgently needed. Here, we evaluated the antiviral activity of a remdesivir parent...

authors： Shi Y,Shuai L,Wen Z,Wang C,Yan Y,Jiao Z,Guo F,Fu ZF,Chen H,Bu Z,Peng G

更新日期：2021-12-01 00:00:00

abstract：:Mycoplasmas, the smallest bacteria lacking a cell wall, can cause various diseases in both humans and animals. Mycoplasmas harbor a variety of virulence factors that enable them to overcome numerous barriers of entry into the host; using accessory proteins, mycoplasma adhesins can bind to the receptors or extracellula...

authors： Yiwen C,Yueyue W,Lianmei Q,Cuiming Z,Xiaoxing Y

更新日期：2021-12-01 00:00:00

abstract：:Tissue factor (TF) has been extensively studied for tumor metastasis, but its role in mediating cancer cell adhesion to vasculature remains unknown. This study aimed to measure the ability of TF to mediate the adhesion of breast cancer cells to human umbilical vein endothelial cells (HUVECs). MDA-MB-231 cells expresse...

authors： Jin Y,Liu W,Wang F,Wang M,Xu K,Yang A,Wang C,Zhang L,Zhang F,Li M

更新日期：2021-12-01 00:00:00

abstract：:Osteoporosis, an aging-associated bone metabolic disease, is affecting millions of people worldwide. The deregulated process of osteoblastic differentiation has been linked with the progression of osteoporosis. Trelagliptin is a long-acting inhibitor of DPP-4 used for the management of type 2 diabetes mellitus. Howeve...

authors： Shao H,Wu R,Cao L,Gu H,Chai F

更新日期：2021-12-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) of the ST1-SCCmecIV lineage has been associated with community-acquired (CA) infections in North America and Australia. In Brazil, multi-drug resistant ST1-SCCmecIV MRSA has emerged in hospital-associated (HA) diseases in Rio de Janeiro. To understand these epidemiolo...

authors： Côrtes MF,Botelho AMN,Bandeira PT,Mouton W,Badiou C,Bes M,Lima NCB,Soares AER,Souza RC,Almeida LGP,Martins-Simoes P,Vasconcelos ATR,Nicolás MF,Laurent F,Planet PJ,Figueiredo AMS

更新日期：2021-12-01 00:00:00

abstract：:The factors that influence patient healthcare experiences are complex and connected to place. In northern Canada, the socio-historical context and the inequitable distribution of health services are unique influences on patients. The objective of this study was to examine the characteristics of patient healthcare expe...

authors： Cooper R,Pollock NJ,Affleck Z,Bain L,Hansen NL,Robertson K,Chatwood S

更新日期：2021-12-01 00:00:00

abstract：:The aim of this paper was to utilise an existing in vitro setup to quantify the oxygen offloading capabilities of two different subsets of injectable oxygenation therapeutics: (1) artificial oxygen carriers (AOCs), which bind or dissolve oxygen and act as transport vectors, and (2) kosmotropes, which increase water hy...

authors： Jayaraman MS,Graham K,Unger EC

更新日期：2021-12-01 00:00:00